In Israel, Infections Drop Sharply After One Shot of Vaccine

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JERUSALEM — Israel, which leads the world in vaccinating its population against the coronavirus, has produced some encouraging news: Early results show a significant drop in infection after just one shot of a two-dose vaccine, and better than expected results after both doses.

Public health experts caution that the data, based on the Pfizer-BioNTech vaccine, is preliminary and has not been subjected to clinical trials. Even so, Dr. Anat Ekka Zohar, vice president of Maccabi Health Services, one of the Israeli health maintenance organizations that released the data, called it “very encouraging.”

In the first early report, Clalit, Israel’s largest health fund, compared 200,000 people aged 60 or over who received a first dose of the vaccine to a matched group of 200,000 who had not been vaccinated yet. It said that 14 to 18 days after their shots, the partially vaccinated patients were 33 percent less likely to be infected.

At about the same time, Maccabi’s research arm said it had found an even larger drop in infections after just one dose: a decrease of about 60 percent, 13 to 21 days after the first shot, in the first 430,000 people to receive it.

Maccabi did not specify an age group or whether it had compared the data with a matched, non-vaccinated cohort.

On Monday, the Israeli Health Ministry and Maccabi released new data on people who had received both doses of the vaccine, showing extremely high rates of effectiveness.

The ministry found that out of 428,000 Israelis who had received their second doses, a week later only 63, or 0.014 percent, had contracted the virus. Similarly, the Maccabi data showed that more than a week after having received the second dose, only 20 out of roughly 128,600 people, about 0.01 percent, had contracted the virus.

In clinical trials the Pfizer vaccine proved 95 percent effective after two doses in preventing coronavirus infection in people without evidence of previous infection. The Israeli results, if they hold up, suggest the efficacy could be even higher, though rigorous comparisons to unvaccinated people have not yet been published.

“This is very encouraging data,” Dr. Zohar said. “We will monitor these patients closely in order to examine if they continue to suffer from mild symptoms only and do not develop complications as a result of the virus.”

Both Clalit and Maccabi warned that their findings were preliminary and said they would soon be followed by more in-depth statistical analysis in peer-reviewed scientific publications.

Israel, where more than 30 percent of the population has already received a first dose of the vaccine, has become something of an international test case for vaccination efficacy.

With its small population, highly digitized universal health system, and rapid, military-assisted vaccine rollout, Israel’s real-world data provides a useful supplement to clinical trials for researchers, pharmaceutical companies and policymakers.

Israel made a deal with Pfizer in which the drug company ensured the country an early and steady supply of vaccines in exchange for data. The Health Ministry has made public a redacted version of the agreement.

Despite its race to vaccinate, Israel is suffering a devastating third wave of the coronavirus. The government reimposed a strict national lockdown this month after weeks of soaring infections and deaths.

Israel was set to halt most air travel in and out of the country starting at midnight on Monday in an effort to block the arrival of emerging virus variants that could threaten the country’s vaccination campaign. Two vaccine makers said Monday that their vaccines were slightly less effective against one of the new variants.

While real-world data like that from Israel is useful, it is subject to variables that can skew the results and which clinical trials try to account for.

The early Israeli numbers are based on the first people to get the vaccine. Such people, experts say, are likely to be more concerned or informed about the virus and therefore more careful about social distancing and mask wearing. They could also differ from those who did not rush to get the shot by location and socio-economic status.

Also, experts say, the disease changes over time. Prof. Ran Balicer, the chief innovation officer at Clalit and a leading Israeli epidemiologist, said that two-week-old data can be like evidence from a different era or “about a million vaccines ago in Israeli terms.”

Maccabi said that it would release more data weekly. “The main message,” Maccabi said in a statement, is that even the first dose of the vaccine “is effective and reduces morbidity and lowers hospitalizations by many tens of percent.”

A hazard of releasing raw data, experts cautioned, is that it can be misinterpreted.

After Clalit first publicized its early numbers two weeks ago, many people heard about a 33 percent drop in cases, not the expected 95 percent, and jumped to the erroneous conclusion that the Pfizer shot didn’t work.

There was an uproar in Britain, where the authorities have delayed giving the second dose by up to 12 weeks, as opposed to the 21-day gap on which Pfizer based its trials.

Professor Balicer thought of the results as good news and was dismayed at how they were interpreted.

“We were reassured enough to tell everyone that we were seeing what we were supposed to be seeing right after Day 14,” he said. “I don’t know how it turned into a message of ‘Oh my God, it doesn’t work.’”

Professor Balicer, who is also the chairman of the team of experts advising the Israeli government on its Covid-19 response, hoped the positive results might have a bearing on an imminent government decision regarding a third lockdown.

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Answers to Your Vaccine Questions

Currently more than 150 million people — almost half the population — are eligible to be vaccinated. But each state makes the final decision about who goes first. The nation’s 21 million health care workers and three million residents of long-term care facilities were the first to qualify. In mid-January, federal officials urged all states to open up eligibility to everyone 65 and older and to adults of any age with medical conditions that put them at high risk of becoming seriously ill or dying from Covid-19. Adults in the general population are at the back of the line. If federal and state health officials can clear up bottlenecks in vaccine distribution, everyone 16 and older will become eligible as early as this spring or early summer. The vaccine hasn’t been approved in children, although studies are underway. It may be months before a vaccine is available for anyone under the age of 16. Go to your state health website for up-to-date information on vaccination policies in your area

You should not have to pay anything out of pocket to get the vaccine, although you will be asked for insurance information. If you don’t have insurance, you should still be given the vaccine at no charge. Congress passed legislation this spring that bars insurers from applying any cost sharing, such as a co-payment or deductible. It layered on additional protections barring pharmacies, doctors and hospitals from billing patients, including those who are uninsured. Even so, health experts do worry that patients might stumble into loopholes that leave them vulnerable to surprise bills. This could happen to those who are charged a doctor visit fee along with their vaccine, or Americans who have certain types of health coverage that do not fall under the new rules. If you get your vaccine from a doctor’s office or urgent care clinic, talk to them about potential hidden charges. To be sure you won’t get a surprise bill, the best bet is to get your vaccine at a health department vaccination site or a local pharmacy once the shots become more widely available.

That is to be determined. It’s possible that Covid-19 vaccinations will become an annual event, just like the flu shot. Or it may be that the benefits of the vaccine last longer than a year. We have to wait to see how durable the protection from the vaccines is. To determine this, researchers are going to be tracking vaccinated people to look for “breakthrough cases” — those people who get sick with Covid-19 despite vaccination. That is a sign of weakening protection and will give researchers clues about how long the vaccine lasts. They will also be monitoring levels of antibodies and T cells in the blood of vaccinated people to determine whether and when a booster shot might be needed. It’s conceivable that people may need boosters every few months, once a year or only every few years. It’s just a matter of waiting for the data.

“Covid has turned us all into amateur scientists,” said Talya Miron-Shatz, an associate professor and expert in medical decision-making at Ono Academic College in central Israel. “We are all looking at data, but most people are not scientists.”

Israel, which began vaccinating people on Dec. 20, has given a first shot to more than 2.6 million Israelis and both shots to more than a million people.

After starting with people aged 60 and above, health care workers and others at high risk, Israel is now offering vaccines to people over 40 and to high school students aged 16 to 18 to allow them to get back to school. The military is assisting the effort and 700 army reserve medics are helping at vaccination centers.

Prof. Jonathan Halevy, the president of Shaare Zedek Medical Center in Jerusalem, had not studied the findings of the H.M.O.s but said that two weeks after the first dose was rolled out he began seeing a drop in severe cases.

“I know several people who became infected close to the time they got the vaccine, but they got it lightly,” he said.

Still, Israel remains under a national lockdown and officials are concerned about the emergence of new, highly contagious variants. It remains to be seen how effective the vaccines are against the new variants.

Despite what appears to be the early success of the vaccine, the virus continues to wreak havoc in Israel. Professor Halevy said his hospital’s Covid wards were still packed to capacity and he expected that it would take another two or three weeks to see a decline.

The virus has killed more than 1,000 Israelis so far this month alone, nearly a quarter of those who have died from the pandemic virus overall.

Health officials and experts have attributed much of the recent increase in infection to the fast-spreading variant first detected in Britain.



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