According to the case statement, one Akhi Akter, 25, and some other men picked up the victim from Sonar Bangla Plaza area on Saturday afternoon over previous enmity.
They took the housewife in an abandoned building inside Pachchar Bakhorerkandi Project where the victim was, first, beaten and, later, gang raped by three men.
Later, when they were transferring the victim to another place by a three-wheeler, the housewife screamed for help.
Hearing cry for help, locals rescued the victim, but the accused managed to flee the scene.
The victim field a case with Shibchar Police Station at night.
The Police Station officer in-charge (OC) Miraz Hossain said police arrested two accused including sex worker Akhi and police are trying to arrest the other accused.
The victim was sent to Madaripur Sadar Hospital for medical test, said investigation officer Md Amir Hossain.